When complex becomes simple...

Our approach.

We endeavor to providing accurate AI-based algorithms to cardiac electrophysiologists. Our first product, AIFib, is designed to outperform human experts in intracardiac multipolar signal analysis. AIFIb delivers AI-based knowledge to operators while they intervene on patients.

About Interventional Electrophysiology

Interventional electrophysiology is a surgical specialty that requires multiple years of experience. It consists of conducting intra-cardiac procedures designed to cure cardiac arrhythmias. During a procedure, an ablationist is required to comprehend a large amount of information. On the one hand, visual analysis of multiple -up to 30- electrograms displayed in real-time is essential. On the other, a large amount of non-electrogram information coming from multiple sources has to be taken into account. This heterogeneous flow of data has to be interpreted in real time so as to progress through the multiple-step workflow of any given procedure.

About Atrial Fibrillation

AF is the most common heart rhythm disturbance in adults (a.k.a atrial arrhythmia). In AF patients the normal beating in the upper chambers of the heart — the two atria — is fast and irregular, and blood doesn’t flow properly from the atria to the lower chambers of the heart—the two ventricles. Such rapid and irregular activity of the atria may be recorded by an electrocardiogram (ECG). ECG signals allow for AF diagnosis in the clinical setting while the duration of arrhythmia episodes define AF sub-types. AF may occur in brief episodes, a.k.a paroxysmal AF, or as a more permanent condition, a.k.a persistent AF.

AF can damage and weaken the heart over time through electrical “remodeling” that occurs in response to both functional— i.e. altered electrical activation— and structural— i.e. heart failure, myocardial fibrosis, etc.—  stressors. Not only are the function and size of the heart severely altered by AF but the “shivering” of the heart’s upper chambers predisposes to clot formation and stroke.

33.5 million individuals worldwide are affected by AF1. In Europe, approximately 11 million individuals have AF and this number is estimated to grow to 14-17 million by 2030, with 120 000 to 215 000 new cases expected every single year2,3. Evidence suggest a greater AF prevalence in patients with conditions such as hypertension, heart failure, coronary artery disease, obesity, diabetes.

Recent studies show that 20–30% of patients with an ischemic stroke have had AF before, during, or after the initial event. AF indeed increases the probability of stroke in four to five times. Furthermore, AF-induced strokes are associated with more severe outcomes. For example, AF-related strokes cause brain white matter lesions, cognitive impairment, decreased quality of life and depressed mood as well as an astonishing hospitalization rate of 10–40% annually4.

References :

  1. Chugh SS, Havmoeller R, Narayannan K, et al. Worldwide epidemiology of atrial fibrillation: A global burden of disease 2010 study. Circulation 2014; 129:837–847
  2. 2017 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. European Heart Journal. 2016;37:2893–2962.doi:10.1093/eurheartj/ehw210
  3. Calkins, Hugh, et al. “HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for personnel, policy, procedures and follow-up: a report of the Heart Rhythm Society (HRS) task force on catheter and surgical ablation of atrial fibrillation. Developed in partnership with the European Heart Rhythm Association (EHRA) and the European Cardiac Arrhythmia Society (ECAS); in collaboration with the American College of Cardiology (ACC), American Heart Association (AHA), and the ….” Heart rhythm 4.6 (2007): 816-861
  4. Authors/Task Force Members:, et al. “2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS.” EP Europace 18.11 (2016): 1609-1678.
  5. Alevizos, Sotiris, et al. “The dynamics of multiscale, multiphysics faults: Part II-Episodic stick-slip can turn the jelly sandwich into a crème brûlée.” Tectonophysics (2017)